Unusual cause of the red penis: sperm allergy

The sport of a red penis can be a source of pride or concern. When a man’s penis health is good, his erect penis often has a red hue due to the blood rushing in and filling the organ. But sometimes a red penis is due to a rash, an allergy or any number of other causes. One of the most mysterious and unusual (and fortunately rare) causes? An allergy to one’s own seed. And worse, that allergy can produce more than just a red penis.

Sperm allergy

It has long been known that some women may be allergic to a man’s semen (or, more precisely, to the semen of one or more men). For such women, when a man ejaculates in their vagina or on or in other parts of the body, they may develop a rash or itching. Burning and swelling are not uncommon; in some cases, a woman may burst into hives or even develop problems with breathing. It can become quite serious.


However, information on sperm allergy in men is more limited. It was first described in 2002 and received the name of post orgasmic disease syndrome (POIS). As with women, expelling semen from the penis in men with POIS can cause red penis irritation or penile eruption. Itching is not uncommon, and swelling is also a factor for some men.

However, men with POIS are also likely to develop symptoms and problems that go beyond the penis area. A flu-like condition is often found after ejaculation in men with POIS. Their eyes may turn red and itchy, their nose is likely to flow and sneezing may result. In addition, they tend to have a fever and experience a significant level of fatigue – bed rest is often required.

For most men with POIS, reactions can occur if ejaculation is achieved through masturbation or through partner’s sex.


In most cases, the allergic reaction appears to be due to a protein found in the sperm to which the body develops an autoimmune response. But it is interesting to note that men with this reaction do not necessarily have their whole lives.

For example, a boy can masturbate quite happily as a teenager and enjoy many forms of couple sex before developing POIS. It can happen in early adolescence or not show up much later in life.

What is perhaps even more interesting is that the allergic reaction occurs only after the semen has been ejaculated. While the semen is stored in the body, or if a man has sex without ejaculating, there is no reaction to the presence of the semen.


Since the exact cause of the response is unknown, treating a sperm allergy can be difficult. A treatment course that has proven effective for many men is building immunity to it. This typically occurs with a doctor who injects a diluted form of sperm into the body over a long period of time. As the process progresses, the seed becomes less diluted.

Other doctors recommend the use of anti-inflammatories (as prescribed by an allergy specialist) before and / or after sex to possibly reduce the development of post-ejaculatory symptoms.

A sperm allergy isn’t the only cause of a red penis, of course. When that redness is accompanied by irritation or dryness, use a superior penis health cream (healthcare professionals recommend Man1 Man Oil, which is clinically proven to be gentle and safe for the skin) may be appropriate. A man should check the list of ingredients on any cream he considers and make sure it contains powerful moisturizing ingredients to soothe the skin. Shea butter (a high-end emollient) and vitamin E (a natural moisturizer) are ideal and work together to form a blockage of moisture. Thinning the penis skin can also make the penis red more painful, so find a cream that includes alpha lipoic acid. This antioxidant fights free radicals that can make the skin of the penis lose weight.

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